Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis
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Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis. / Jacobsen, Christian Borch; Nielsen, Daniel Steen; Meldal, Morten; Diness, Frederik.
I: Journal of Organic Chemistry, Bind 84, Nr. 11, 07.06.2019, s. 6940-6945.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › fagfællebedømt
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TY - JOUR
T1 - Azotides as Modular Peptide-Based Ligands for Asymmetric Lewis Acid Catalysis
AU - Jacobsen, Christian Borch
AU - Nielsen, Daniel Steen
AU - Meldal, Morten
AU - Diness, Frederik
PY - 2019/6/7
Y1 - 2019/6/7
N2 - Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hetero Diels-Alder adducts. A rational for the observed enantioselectivity and conversion rate supported by computational calculations is provided.
AB - Synthesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is reported. The ligands were readily prepared from the chiral pool of amino acids and perform well in the cobalt(II)-catalyzed formation of asymmetric hetero Diels-Alder adducts. A rational for the observed enantioselectivity and conversion rate supported by computational calculations is provided.
U2 - 10.1021/acs.joc.9b00732
DO - 10.1021/acs.joc.9b00732
M3 - Journal article
C2 - 31033291
AN - SCOPUS:85066611116
VL - 84
SP - 6940
EP - 6945
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
SN - 0022-3263
IS - 11
ER -
ID: 231361334