C-Terminal lactamization of peptides

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Solid-phase synthesis of peptides (SPPS) with release through formation of C-terminal γ-, δ-, or ε-lactams is presented. The natural products ciliatamide A and C were synthesized in up to 90% yield. Peptides carrying C-terminal lactams were shown to possess increased bio-stability and comparable biological activity as compared to the parent non-lactamized peptide amides.
OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind57
Udgave nummer7
Sider (fra-til)895-898
Antal sider4
ISSN1359-7345
DOI
StatusUdgivet - 2021

ID: 261160414