Phenazines and natural products; novel synthesis of saphenic acid

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

The natural product saphenic acid (6-(1-hydroxyethyl)1- phenazinecarboxylic acid) was synthesized from readily accessible starting materials. The desired product was obtained in an overall yield of 22% for four steps with the key steps being formation of a diphenylamine, followed by cyclization under alkaline and reducing conditions. Assignments of 1H NMR spectra were achieved by homo- and heteronuclear 1D and 2D correlations. Double pulsed field gradient spin-echo one-dimensional NOESY proved especially valuable for assignment of aromatic protons.

OriginalsprogEngelsk
TidsskriftSynthesis
Udgave nummer10
Sider (fra-til)1763-1766
Antal sider4
ISSN0039-7881
StatusUdgivet - 1 jan. 1999

ID: 131118581