Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. / Clausen, L N; Weis, N; Astvad, K; Schønning, K; Fenger, M; Krarup, H; Bukh, J; Benfield, Thomas Lars.

I: Journal of Viral Hepatitis, Bind 18, Nr. 4, 2011, s. e66-e74.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Clausen, LN, Weis, N, Astvad, K, Schønning, K, Fenger, M, Krarup, H, Bukh, J & Benfield, TL 2011, 'Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort', Journal of Viral Hepatitis, bind 18, nr. 4, s. e66-e74. https://doi.org/10.1111/j.1365-2893.2010.01392.x

APA

Clausen, L. N., Weis, N., Astvad, K., Schønning, K., Fenger, M., Krarup, H., Bukh, J., & Benfield, T. L. (2011). Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. Journal of Viral Hepatitis, 18(4), e66-e74. https://doi.org/10.1111/j.1365-2893.2010.01392.x

Vancouver

Clausen LN, Weis N, Astvad K, Schønning K, Fenger M, Krarup H o.a. Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. Journal of Viral Hepatitis. 2011;18(4):e66-e74. https://doi.org/10.1111/j.1365-2893.2010.01392.x

Author

Clausen, L N ; Weis, N ; Astvad, K ; Schønning, K ; Fenger, M ; Krarup, H ; Bukh, J ; Benfield, Thomas Lars. / Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort. I: Journal of Viral Hepatitis. 2011 ; Bind 18, Nr. 4. s. e66-e74.

Bibtex

@article{46341d1e9a6c414992675a48885eab61,
title = "Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort",
abstract = "Summary. Twenty-five per cent of individuals infected with hepatitis C virus (HCV) are able to clear HCV spontaneously. Differences in host genetics are believed to affect the outcome of HCV infection. We analysed an exonic, a promoter and an intronic single nucleotide polymorphism (SNP) of the interferon-¿3 coding interleukin (IL)-28B gene to study the relationship between IL28B SNPs and outcome of HCV infection. Among 206 HIV-1-infected Europeans with evidence of HCV infection, 47 (23%) individuals had cleared HCV and 159 (77%) had developed chronic infection. The exonic rs8103142 CT, the promoter rs12979860 CT and the intronic rs11881222 AG genotypes were associated with a decreased HCV clearance rate with adjusted odds ratios (aOR) of 0.3 (95% CI, 0.1-0.7), 0.4 (95% CI, 0.2-0.8) and 0.4 (95% CI, 0.2-0.8), respectively. The haplotype block TCG CTA was associated with a decreased HCV clearance rate (aOR 0.4, 95% CI, 0.2-0.8). Further, we found significant differences in HCV RNA levels among individuals chronically infected with HCV genotype 1 for rs8103142 and rs12979860 (P = 0.05). Chronically infected individuals with HCV genotype 3 and with the favourable haplotype block CTA CTA had higher median HCV RNA levels than individuals with unfavourable haplotype blocks (P = 0.05). Our findings suggest that IL28B may account for some differences in HCV outcome but that other factors including the viral genotype, host genetics and the host-virus interaction are likely to influence the outcome of HCV infection.",
author = "Clausen, {L N} and N Weis and K Astvad and K Sch{\o}nning and M Fenger and H Krarup and J Bukh and Benfield, {Thomas Lars}",
note = "{\textcopyright} 2010 Blackwell Publishing Ltd.",
year = "2011",
doi = "10.1111/j.1365-2893.2010.01392.x",
language = "English",
volume = "18",
pages = "e66--e74",
journal = "Journal of Viral Hepatitis",
issn = "1352-0504",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Interleukin-28B polymorphisms are associated with hepatitis C virus clearance and viral load in a HIV-1-infected cohort

AU - Clausen, L N

AU - Weis, N

AU - Astvad, K

AU - Schønning, K

AU - Fenger, M

AU - Krarup, H

AU - Bukh, J

AU - Benfield, Thomas Lars

N1 - © 2010 Blackwell Publishing Ltd.

PY - 2011

Y1 - 2011

N2 - Summary. Twenty-five per cent of individuals infected with hepatitis C virus (HCV) are able to clear HCV spontaneously. Differences in host genetics are believed to affect the outcome of HCV infection. We analysed an exonic, a promoter and an intronic single nucleotide polymorphism (SNP) of the interferon-¿3 coding interleukin (IL)-28B gene to study the relationship between IL28B SNPs and outcome of HCV infection. Among 206 HIV-1-infected Europeans with evidence of HCV infection, 47 (23%) individuals had cleared HCV and 159 (77%) had developed chronic infection. The exonic rs8103142 CT, the promoter rs12979860 CT and the intronic rs11881222 AG genotypes were associated with a decreased HCV clearance rate with adjusted odds ratios (aOR) of 0.3 (95% CI, 0.1-0.7), 0.4 (95% CI, 0.2-0.8) and 0.4 (95% CI, 0.2-0.8), respectively. The haplotype block TCG CTA was associated with a decreased HCV clearance rate (aOR 0.4, 95% CI, 0.2-0.8). Further, we found significant differences in HCV RNA levels among individuals chronically infected with HCV genotype 1 for rs8103142 and rs12979860 (P = 0.05). Chronically infected individuals with HCV genotype 3 and with the favourable haplotype block CTA CTA had higher median HCV RNA levels than individuals with unfavourable haplotype blocks (P = 0.05). Our findings suggest that IL28B may account for some differences in HCV outcome but that other factors including the viral genotype, host genetics and the host-virus interaction are likely to influence the outcome of HCV infection.

AB - Summary. Twenty-five per cent of individuals infected with hepatitis C virus (HCV) are able to clear HCV spontaneously. Differences in host genetics are believed to affect the outcome of HCV infection. We analysed an exonic, a promoter and an intronic single nucleotide polymorphism (SNP) of the interferon-¿3 coding interleukin (IL)-28B gene to study the relationship between IL28B SNPs and outcome of HCV infection. Among 206 HIV-1-infected Europeans with evidence of HCV infection, 47 (23%) individuals had cleared HCV and 159 (77%) had developed chronic infection. The exonic rs8103142 CT, the promoter rs12979860 CT and the intronic rs11881222 AG genotypes were associated with a decreased HCV clearance rate with adjusted odds ratios (aOR) of 0.3 (95% CI, 0.1-0.7), 0.4 (95% CI, 0.2-0.8) and 0.4 (95% CI, 0.2-0.8), respectively. The haplotype block TCG CTA was associated with a decreased HCV clearance rate (aOR 0.4, 95% CI, 0.2-0.8). Further, we found significant differences in HCV RNA levels among individuals chronically infected with HCV genotype 1 for rs8103142 and rs12979860 (P = 0.05). Chronically infected individuals with HCV genotype 3 and with the favourable haplotype block CTA CTA had higher median HCV RNA levels than individuals with unfavourable haplotype blocks (P = 0.05). Our findings suggest that IL28B may account for some differences in HCV outcome but that other factors including the viral genotype, host genetics and the host-virus interaction are likely to influence the outcome of HCV infection.

U2 - 10.1111/j.1365-2893.2010.01392.x

DO - 10.1111/j.1365-2893.2010.01392.x

M3 - Journal article

C2 - 21070502

VL - 18

SP - e66-e74

JO - Journal of Viral Hepatitis

JF - Journal of Viral Hepatitis

SN - 1352-0504

IS - 4

ER -

ID: 32087318