Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study
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Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study. / Omland, L H; Jepsen, P; Weis, N; Christensen, P B; Laursen, A L; Nielsen, H; Krarup, H; Sørensen, H T; Obel, N.
I: Journal of Viral Hepatitis, Bind 17, Nr. 4, 2010, s. 261-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mortality in HIV-infected injection drug users with active vs cleared hepatitis C virus-infection: a population-based cohort study
AU - Omland, L H
AU - Jepsen, P
AU - Weis, N
AU - Christensen, P B
AU - Laursen, A L
AU - Nielsen, H
AU - Krarup, H
AU - Sørensen, H T
AU - Obel, N
N1 - Keywords: Adult; Cohort Studies; Denmark; Drug Users; Female; HIV Infections; Hepatitis C; Hepatitis Viruses; Humans; Male; Middle Aged; Substance Abuse, Intravenous; Survival Analysis
PY - 2010
Y1 - 2010
N2 - Acute hepatitis C virus (HCV) infection may lead to chronic HCV-infection with detectable HCV RNA or to spontaneous clearance with no HCV RNA, but detectable HCV antibodies. It is unknown whether HCV RNA status is associated with mortality in HIV-infected injection drug users (IDUs). We conducted a nationwide population-based cohort study to examine the impact of HCV RNA status on overall and cause-specific mortality in HIV-infected IDUs. We computed cumulative mortality and used Cox Regression to estimate mortality rate ratios (MRR). We identified 392 HIV-infected patients of whom 284 (72%) had chronic HCV-infection (HCV RNA positive patients) and 108 (28%) had cleared the HCV-infection (HCV RNA negative patients). During 1286 person-years of observation (PYR), 157 persons died (MR = 122/1000 PYR, 95% CI: 104-143). The estimated 5-year probabilities of survival were 0.58 (95% CI: 0.51-0.65) in the chronically HCV-infected and 0.52 (95% CI: 0.40-0.63) in the cleared HCV group. Chronic HCV-infection was not associated with overall mortality: MRR 0.85, 95% CI: 0.59-1.21. In HIV-infected Danish IDUs, chronic HCV-infection is not associated with increased mortality compared to patients who have cleared the infection.
AB - Acute hepatitis C virus (HCV) infection may lead to chronic HCV-infection with detectable HCV RNA or to spontaneous clearance with no HCV RNA, but detectable HCV antibodies. It is unknown whether HCV RNA status is associated with mortality in HIV-infected injection drug users (IDUs). We conducted a nationwide population-based cohort study to examine the impact of HCV RNA status on overall and cause-specific mortality in HIV-infected IDUs. We computed cumulative mortality and used Cox Regression to estimate mortality rate ratios (MRR). We identified 392 HIV-infected patients of whom 284 (72%) had chronic HCV-infection (HCV RNA positive patients) and 108 (28%) had cleared the HCV-infection (HCV RNA negative patients). During 1286 person-years of observation (PYR), 157 persons died (MR = 122/1000 PYR, 95% CI: 104-143). The estimated 5-year probabilities of survival were 0.58 (95% CI: 0.51-0.65) in the chronically HCV-infected and 0.52 (95% CI: 0.40-0.63) in the cleared HCV group. Chronic HCV-infection was not associated with overall mortality: MRR 0.85, 95% CI: 0.59-1.21. In HIV-infected Danish IDUs, chronic HCV-infection is not associated with increased mortality compared to patients who have cleared the infection.
U2 - 10.1111/j.1365-2893.2009.01175.x
DO - 10.1111/j.1365-2893.2009.01175.x
M3 - Journal article
C2 - 19709359
VL - 17
SP - 261
EP - 268
JO - Journal of Viral Hepatitis
JF - Journal of Viral Hepatitis
SN - 1352-0504
IS - 4
ER -
ID: 21456948