Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

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Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

OriginalsprogEngelsk
Artikelnummer1389
TidsskriftMolecules
Vol/bind25
Udgave nummer6
Sider (fra-til)1-13
ISSN1420-3049
DOI
StatusUdgivet - 2020

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