Chemistry Seminar Series: Prof. Jérôme Lacour
On 12 september professor Jérôme Lacour from University of Geneva will give a talk titled 'Stereoselective Synthesis & Catalysis with Chiral Helicenes and Reactive Metal Carbenes'.
Recent studies on the synthesis and properties of cationic  and helicenes will be presented. Some of these derivatives can be prepared on gram-scale in two steps only. Single enantiomers display original biological, chemical and physical properties. A focus will be given on regio-divergent post-functionalization routes, as late introduction of substituents allows a tuning of many properties, among which electronic absorption, CD/CPL and fluorescence near or within the biological transparency window.
Recent progress on metal-catalyzed reactions and processes will also be presented – and those involving dirhodium, CpRu and copper catalyzed decompositions of α-diazocarbonyls in particular. An attention will be given to routes affording ylide intermediates and then functionally rich heterocyclic derivatives. A large variety of stereoselective and enantiospecific transformations are available through these metal carbene reactions and subsequent ylide chemistries. Mechanistic investigations and a variety of applications will be also detailed during the lecture.