Asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens
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A new asymmetric transesterification of secondary alcohols catalyzed by feruloyl esterase from Humicola insolens has been found. Although alcohols are not the natural substrates for this enzyme, a high R enantioselectivity was observed. Stereochemical studies showed that variations in substrate structure lead to strong variations in enantioselectivity. The highest enantioselectivities are obtained when the β-carbon of the secondary alcohol is tertiary or quaternary.
Originalsprog | Engelsk |
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Tidsskrift | Bioorganic Chemistry |
Vol/bind | 33 |
Udgave nummer | 4 |
Sider (fra-til) | 325-337 |
Antal sider | 13 |
ISSN | 0045-2068 |
DOI | |
Status | Udgivet - 2005 |
Eksternt udgivet | Ja |
ID: 286412469