Linkers, resins, and general procedures for solid-phase peptide synthesis
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Linkers, resins, and general procedures for solid-phase peptide synthesis. / Shelton, Anne Pernille Tofteng; Jensen, Knud Jørgen.
Peptide synthesis and applications. red. / Knud J. Jensen; Pernille T. Shelton; Søren L. Pedersen. Humana Press, 2013. s. 23-41 (Methods in Molecular Biology, Bind 1047).Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - Linkers, resins, and general procedures for solid-phase peptide synthesis
AU - Shelton, Anne Pernille Tofteng
AU - Jensen, Knud Jørgen
PY - 2013
Y1 - 2013
N2 - This chapter describes the basic protocols for solid-phase peptide synthesis using the Fmoc group as the N-alpha-protecting group (Fmoc-SPPS). The chapter introduces resins and their handling, choice of linkers, and the most common methods for peptide chain assembly. The proper choice of resins and linkers for solid-phase synthesis is a key parameter for successful peptide synthesis. This chapter provides an overview of the most common and useful resins and linkers for the synthesis of peptides with C-terminal amides, carboxylic acids, and more. The chapter finishes with robust protocols for general solid-phase peptide synthesis, i.e., the standard operations.
AB - This chapter describes the basic protocols for solid-phase peptide synthesis using the Fmoc group as the N-alpha-protecting group (Fmoc-SPPS). The chapter introduces resins and their handling, choice of linkers, and the most common methods for peptide chain assembly. The proper choice of resins and linkers for solid-phase synthesis is a key parameter for successful peptide synthesis. This chapter provides an overview of the most common and useful resins and linkers for the synthesis of peptides with C-terminal amides, carboxylic acids, and more. The chapter finishes with robust protocols for general solid-phase peptide synthesis, i.e., the standard operations.
KW - Solid-phase peptide synthesis
KW - SPPS
KW - TentaGel
KW - ChemMatrix
KW - PEGA
KW - Polystyrene
KW - HBTU
KW - HATU
KW - DIC
KW - COMU
KW - HOBt
KW - HOAt
KW - Oxyma
U2 - 10.1007/978-1-62703-544-6_2
DO - 10.1007/978-1-62703-544-6_2
M3 - Book chapter
C2 - 23943476
SN - 978-1-62703-543-9
T3 - Methods in Molecular Biology
SP - 23
EP - 41
BT - Peptide synthesis and applications
A2 - Jensen, Knud J.
A2 - Shelton, Pernille T.
A2 - Pedersen, Søren L.
PB - Humana Press
ER -
ID: 118886496