TY - JOUR

T1 - Postbiotics versus probiotics in early-onset colorectal cancer

AU - Feizi, Hadi

AU - Plotnikov, Andrey

AU - Rezaee, Mohammad Ahangarzadeh

AU - Ganbarov, Khudaverdi

AU - Kamounah, Fadhil S.

AU - Nikitin, Sergei

AU - Kadkhoda, Hiva

AU - Gholizadeh, Pourya

AU - Pagliano, Pasquale

AU - Kafil, Hossein Samadi

N1 - Publisher Copyright: © 2022 Taylor & Francis Group, LLC.

PY - 2024

Y1 - 2024

N2 - Probiotics and postbiotics mechanisms of action and applications in early-onset colorectal cancer (EOCRC) prevention and treatment have significant importance but are a matter of debate and controversy. Therefore, in this review, we aimed to define the probiotics concept, advantages and limitations in comparison to postbiotics, and proposed mechanisms of anti-tumor action in EOCRC prevention and treatment of postbiotics. Biotics (probiotics, prebiotics, and postbiotics) could confer the health benefit by affecting the host gut microbiota directly and indirectly. The main mechanisms of action of probiotics in exerting anticancer features include immune system regulation, inhibition of cancer cell propagation, gut dysbiosis restoration, anticancer agents’ production, gut barrier function renovation, and cancer-promoting agents’ reduction. Postbiotics are suggested to have different mechanisms of action to restore eubiosis against EOCRC, including modulation of gut microbiota composition, gut microbial metabolites regulation, and intestinal barrier function improvement via different features such as immunomodulatory, anti-inflammatory, antioxidant, and anti-proliferative properties. A better understanding of postbiotics challenges and mechanism of action in therapeutic applications will allow us to sketch accurate trials in order to use postbiotics as bio-therapeutics in EOCRC.

AB - Probiotics and postbiotics mechanisms of action and applications in early-onset colorectal cancer (EOCRC) prevention and treatment have significant importance but are a matter of debate and controversy. Therefore, in this review, we aimed to define the probiotics concept, advantages and limitations in comparison to postbiotics, and proposed mechanisms of anti-tumor action in EOCRC prevention and treatment of postbiotics. Biotics (probiotics, prebiotics, and postbiotics) could confer the health benefit by affecting the host gut microbiota directly and indirectly. The main mechanisms of action of probiotics in exerting anticancer features include immune system regulation, inhibition of cancer cell propagation, gut dysbiosis restoration, anticancer agents’ production, gut barrier function renovation, and cancer-promoting agents’ reduction. Postbiotics are suggested to have different mechanisms of action to restore eubiosis against EOCRC, including modulation of gut microbiota composition, gut microbial metabolites regulation, and intestinal barrier function improvement via different features such as immunomodulatory, anti-inflammatory, antioxidant, and anti-proliferative properties. A better understanding of postbiotics challenges and mechanism of action in therapeutic applications will allow us to sketch accurate trials in order to use postbiotics as bio-therapeutics in EOCRC.

KW - Early-onset colorectal cancer (EOCRC)

KW - gut microbiota

KW - postbiotics

KW - prebiotics

KW - probiotics

U2 - 10.1080/10408398.2022.2132464

DO - 10.1080/10408398.2022.2132464

M3 - Review

C2 - 36250549

AN - SCOPUS:85139970167

VL - 64

SP - 3573

EP - 3582

JO - Critical Reviews in Food Science and Nutrition

JF - Critical Reviews in Food Science and Nutrition

SN - 1040-8398

IS - 11

ER -