Silyl-protective groups influencing the reactivity and selectivity in glycosylations

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Dokumenter

Silyl groups such as TBDPS, TBDMS, TIPS or TMS are well-known and widely used alcohol protective groups in organic chemistry. Cyclic silylene protective groups are also becoming increasingly popular. In carbohydrate chemistry silyl protective groups have frequently been used primarily as an orthogonal protective group to the more commonly used acyl and benzyl protective groups. However, silyl protective groups have significantly different electronic and steric requirements than acyl and alkyl protective groups, which particularly becomes important when two or more neighboring alcohols are silyl protected. Within the last decade polysilylated glycosyl donors have been found to have unusual properties such as high (or low) reactivity or high stereoselectivity. This mini review will summarize these findings
OriginalsprogEngelsk
TidsskriftBeilstein Journal of Organic Chemistry
Vol/bind13
Sider (fra-til)93-105
Antal sider13
ISSN2195-951X
DOI
StatusUdgivet - 2017

Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk


Ingen data tilgængelig

ID: 176370769