Solid-phase synthesis of biarylalanines via Suzuki cross-coupling and intramolecular N-acyliminium Pictet-Spengler reactions
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Solid-supported masked peptide aldehydes containing 3- or 4-iodophenylalanine residues were subjected to Pd-catalyzed Suzuki cross-coupling reactions with arylboronic acids. The biarylalanines generated were applied in intramolecular N-acyliminium Pictet-Spengler reactions. In this way, a range of pharmacologically interesting aryl-substituted pyrroloisoquinolines was obtained in excellent purity (>95%).
Originalsprog | Engelsk |
---|---|
Tidsskrift | Tetrahedron Letters |
Vol/bind | 46 |
Udgave nummer | 46 |
Sider (fra-til) | 7959-7962 |
Antal sider | 4 |
ISSN | 0040-4039 |
DOI | |
Status | Udgivet - 14 nov. 2005 |
Eksternt udgivet | Ja |
Bibliografisk note
Funding Information:
The Danish National Research Foundation is gratefully acknowledged for financial support.
ID: 326846788