Total synthesis of five lipoteichoic acids of Clostridium difficile

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Standard

Total synthesis of five lipoteichoic acids of Clostridium difficile. / Hogendorf, Wouter Frederik Johan; Gisch, Nicolas; Schwudke, Dominik; Heine, Holger; Bols, Mikael; Pedersen, Christian Marcus.

I: Chemistry: A European Journal, Bind 20, Nr. 42, 2014, s. 13511-13516.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hogendorf, WFJ, Gisch, N, Schwudke, D, Heine, H, Bols, M & Pedersen, CM 2014, 'Total synthesis of five lipoteichoic acids of Clostridium difficile', Chemistry: A European Journal, bind 20, nr. 42, s. 13511-13516. https://doi.org/10.1002/chem.201404336

APA

Hogendorf, W. F. J., Gisch, N., Schwudke, D., Heine, H., Bols, M., & Pedersen, C. M. (2014). Total synthesis of five lipoteichoic acids of Clostridium difficile. Chemistry: A European Journal, 20(42), 13511-13516. https://doi.org/10.1002/chem.201404336

Vancouver

Hogendorf WFJ, Gisch N, Schwudke D, Heine H, Bols M, Pedersen CM. Total synthesis of five lipoteichoic acids of Clostridium difficile. Chemistry: A European Journal. 2014;20(42):13511-13516. https://doi.org/10.1002/chem.201404336

Author

Hogendorf, Wouter Frederik Johan ; Gisch, Nicolas ; Schwudke, Dominik ; Heine, Holger ; Bols, Mikael ; Pedersen, Christian Marcus. / Total synthesis of five lipoteichoic acids of Clostridium difficile. I: Chemistry: A European Journal. 2014 ; Bind 20, Nr. 42. s. 13511-13516.

Bibtex

@article{d8d4834bc37443f685aaa9cc57a5787f,
title = "Total synthesis of five lipoteichoic acids of Clostridium difficile",
abstract = "The emergence of hypervirulent resistant strains have made Clostridium difficile a notorious nosocomial pathogen and has resulted in a renewed interest in preventive strategies, such as vaccines based on (synthetic) cell wall antigens. Recently, the structure of the lipoteichoic acid (LTA) of this species has been elucidated. Additionally, this LTA was found to induce the formation of protective antibodies against C. difficile in rabbits and mice. The LTA from C. difficile is isolated as a microheterogenous mixture, differing in size and composition, impeding any structure-activity relationship studies. To ensure reliable biological results, pure and well-defined synthetic samples are required. In this work the total synthesis of LTAs from C. difficile with defined chain length is described and the initial biological results are presented.",
author = "Hogendorf, {Wouter Frederik Johan} and Nicolas Gisch and Dominik Schwudke and Holger Heine and Mikael Bols and Pedersen, {Christian Marcus}",
note = "{\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2014",
doi = "10.1002/chem.201404336",
language = "English",
volume = "20",
pages = "13511--13516",
journal = "Chemistry: A European Journal",
issn = "0947-6539",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "42",

}

RIS

TY - JOUR

T1 - Total synthesis of five lipoteichoic acids of Clostridium difficile

AU - Hogendorf, Wouter Frederik Johan

AU - Gisch, Nicolas

AU - Schwudke, Dominik

AU - Heine, Holger

AU - Bols, Mikael

AU - Pedersen, Christian Marcus

N1 - © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2014

Y1 - 2014

N2 - The emergence of hypervirulent resistant strains have made Clostridium difficile a notorious nosocomial pathogen and has resulted in a renewed interest in preventive strategies, such as vaccines based on (synthetic) cell wall antigens. Recently, the structure of the lipoteichoic acid (LTA) of this species has been elucidated. Additionally, this LTA was found to induce the formation of protective antibodies against C. difficile in rabbits and mice. The LTA from C. difficile is isolated as a microheterogenous mixture, differing in size and composition, impeding any structure-activity relationship studies. To ensure reliable biological results, pure and well-defined synthetic samples are required. In this work the total synthesis of LTAs from C. difficile with defined chain length is described and the initial biological results are presented.

AB - The emergence of hypervirulent resistant strains have made Clostridium difficile a notorious nosocomial pathogen and has resulted in a renewed interest in preventive strategies, such as vaccines based on (synthetic) cell wall antigens. Recently, the structure of the lipoteichoic acid (LTA) of this species has been elucidated. Additionally, this LTA was found to induce the formation of protective antibodies against C. difficile in rabbits and mice. The LTA from C. difficile is isolated as a microheterogenous mixture, differing in size and composition, impeding any structure-activity relationship studies. To ensure reliable biological results, pure and well-defined synthetic samples are required. In this work the total synthesis of LTAs from C. difficile with defined chain length is described and the initial biological results are presented.

U2 - 10.1002/chem.201404336

DO - 10.1002/chem.201404336

M3 - Journal article

C2 - 25168290

VL - 20

SP - 13511

EP - 13516

JO - Chemistry: A European Journal

JF - Chemistry: A European Journal

SN - 0947-6539

IS - 42

ER -

ID: 127999025