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Probing the aglycon binding site of a beta-glucosidase : a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors. / Wrodnigg, Tanja M; Diness, Frederik; Gruber, Christoph; Häusler, Herwig; Lundt, Inge; Rupitz, Karen; Steiner, Andreas J; Stütz, Arnold E; Tarling, Chris A; Withers, Stephen G; Wölfler, Heidrun.
I:
Bioorganic & Medicinal Chemistry, Bind 12, Nr. 13, 01.07.2004, s. 3485-95.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Wrodnigg, TM
, Diness, F, Gruber, C, Häusler, H, Lundt, I, Rupitz, K, Steiner, AJ, Stütz, AE, Tarling, CA, Withers, SG & Wölfler, H 2004, '
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors',
Bioorganic & Medicinal Chemistry, bind 12, nr. 13, s. 3485-95.
https://doi.org/10.1016/j.bmc.2004.04.037APA
Wrodnigg, T. M.
, Diness, F., Gruber, C., Häusler, H., Lundt, I., Rupitz, K., Steiner, A. J., Stütz, A. E., Tarling, C. A., Withers, S. G., & Wölfler, H. (2004).
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Bioorganic & Medicinal Chemistry,
12(13), 3485-95.
https://doi.org/10.1016/j.bmc.2004.04.037Vancouver
Wrodnigg TM
, Diness F, Gruber C, Häusler H, Lundt I, Rupitz K o.a.
Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors.
Bioorganic & Medicinal Chemistry. 2004 jul. 1;12(13):3485-95.
https://doi.org/10.1016/j.bmc.2004.04.037Author
Wrodnigg, Tanja M ; Diness, Frederik ; Gruber, Christoph ; Häusler, Herwig ; Lundt, Inge ; Rupitz, Karen ; Steiner, Andreas J ; Stütz, Arnold E ; Tarling, Chris A ; Withers, Stephen G ; Wölfler, Heidrun. / Probing the aglycon binding site of a beta-glucosidase : a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors. I: Bioorganic & Medicinal Chemistry. 2004 ; Bind 12, Nr. 13. s. 3485-95.
Bibtex
@article{dbe98caf63e149e29a285085d2b12b47,
title = "Probing the aglycon binding site of a beta-glucosidase: a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors",
abstract = "A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.",
keywords = "Binding, Competitive, Enzyme Inhibitors, Imino Pyranoses, Mannitol, Molecular Structure, Rhizobium, Structure-Activity Relationship, beta-Glucosidase",
author = "Wrodnigg, {Tanja M} and Frederik Diness and Christoph Gruber and Herwig H{\"a}usler and Inge Lundt and Karen Rupitz and Steiner, {Andreas J} and St{\"u}tz, {Arnold E} and Tarling, {Chris A} and Withers, {Stephen G} and Heidrun W{\"o}lfler",
year = "2004",
month = jul,
day = "1",
doi = "10.1016/j.bmc.2004.04.037",
language = "English",
volume = "12",
pages = "3485--95",
journal = "Bioorganic & Medicinal Chemistry",
issn = "0968-0896",
publisher = "Pergamon Press",
number = "13",
}
RIS
TY - JOUR
T1 - Probing the aglycon binding site of a beta-glucosidase
T2 - a collection of C-1-modified 2,5-dideoxy-2,5-imino-D-mannitol derivatives and their structure-activity relationships as competitive inhibitors
AU - Wrodnigg, Tanja M
AU - Diness, Frederik
AU - Gruber, Christoph
AU - Häusler, Herwig
AU - Lundt, Inge
AU - Rupitz, Karen
AU - Steiner, Andreas J
AU - Stütz, Arnold E
AU - Tarling, Chris A
AU - Withers, Stephen G
AU - Wölfler, Heidrun
PY - 2004/7/1
Y1 - 2004/7/1
N2 - A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.
AB - A range of new C-1 modified derivatives of the powerful glucosidase inhibitor 2,5-dideoxy-2,5-imino-D-mannitol has been synthesised and their biological activities probed with the beta-glucosidase from Agrobacterium sp. Ki values are compared with those of previously prepared close relatives. Findings suggest dramatic effects exerted by the aglycon binding site on substrate/inhibitor binding.
KW - Binding, Competitive
KW - Enzyme Inhibitors
KW - Imino Pyranoses
KW - Mannitol
KW - Molecular Structure
KW - Rhizobium
KW - Structure-Activity Relationship
KW - beta-Glucosidase
U2 - 10.1016/j.bmc.2004.04.037
DO - 10.1016/j.bmc.2004.04.037
M3 - Journal article
C2 - 15186833
VL - 12
SP - 3485
EP - 3495
JO - Bioorganic & Medicinal Chemistry
JF - Bioorganic & Medicinal Chemistry
SN - 0968-0896
IS - 13
ER -
