Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle

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Standard

Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle. / Jensen, Ask S.; Pennisi, Cristian P.; Sevcencu, Cristian; Christensen, Jørn B.; Kristiansen, Jette E.; Struijk, Johannes J.

Computing in Cardiology Conference 2015, CinC 2015. red. / Alan Murray. IEEE Computer Society Press, 2015. s. 429-432 7408678 (Computing in Cardiology, Bind 42).

Publikation: Bidrag til bog/antologi/rapport › Konferencebidrag i proceedings › Forskning › fagfællebedømt

Harvard

Jensen, AS, Pennisi, CP, Sevcencu, C, Christensen, JB, Kristiansen, JE & Struijk, JJ 2015, Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle. i A Murray (red.), Computing in Cardiology Conference 2015, CinC 2015., 7408678, IEEE Computer Society Press, Computing in Cardiology, bind 42, s. 429-432, 42nd Computing in Cardiology Conference, CinC 2015, Nice, Frankrig, 06/09/2015. https://doi.org/10.1109/CIC.2015.7408678

APA

Jensen, A. S., Pennisi, C. P., Sevcencu, C., Christensen, J. B., Kristiansen, J. E., & Struijk, J. J. (2015). Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle. I A. Murray (red.), Computing in Cardiology Conference 2015, CinC 2015 (s. 429-432). [7408678] IEEE Computer Society Press. Computing in Cardiology Bind 42 https://doi.org/10.1109/CIC.2015.7408678

Vancouver

Jensen AS, Pennisi CP, Sevcencu C, Christensen JB, Kristiansen JE, Struijk JJ. Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle. I Murray A, red., Computing in Cardiology Conference 2015, CinC 2015. IEEE Computer Society Press. 2015. s. 429-432. 7408678. (Computing in Cardiology, Bind 42). https://doi.org/10.1109/CIC.2015.7408678

Author

Jensen, Ask S. ; Pennisi, Cristian P. ; Sevcencu, Cristian ; Christensen, Jørn B. ; Kristiansen, Jette E. ; Struijk, Johannes J. / Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle. Computing in Cardiology Conference 2015, CinC 2015. red. / Alan Murray. IEEE Computer Society Press, 2015. s. 429-432 (Computing in Cardiology, Bind 42).

Bibtex

@inproceedings{12e6b21d63e24ac29fc349bf9d3ea874,
title = "Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle",
abstract = "Aims: We sought to establish a computational model of the rabbit ventricular action potential (AP) suitable for investigation of drug effects on the AP of the isolated rabbit papillary muscle. Methods: Data consisted of transmembrane AP recordings from isolated right ventricular papillary muscles from 21 rabbits. An existing model of the rabbit ventricular AP was adapted to reproduce experimental AP amplitude and AP duration (APD90, APD60, APD30,) at multiple pacing rates by reduction of fast sodium current and overall depolarizing current. The resulting model was validated. Results: At 2.0 and 0.5 Hz pacing respectively, the experimentally recorded APD90 was 113.9±11.2 ms and 150.2±13.1 ms. The adapted model produced an APD90 of 130.5 ms and 142.5 ms. Validation of the adapted model showed that, while there was a substantial adaptation of the model APD to experimental data, model stability was maintained, and internal Ca dynamics and responses to stimuli were not substantially affected. Conclusion: A model of the rabbit ventricular AP was adapted in order to reproduce experimental AP recordings from the isolated right ventricular rabbit papillary muscle. This model is useful for analysis of drug effects on the rabbit papillary AP.",
author = "Jensen, {Ask S.} and Pennisi, {Cristian P.} and Cristian Sevcencu and Christensen, {J{\o}rn B.} and Kristiansen, {Jette E.} and Struijk, {Johannes J.}",
year = "2015",
month = feb,
day = "16",
doi = "10.1109/CIC.2015.7408678",
language = "English",
series = "Computing in Cardiology",
publisher = "IEEE Computer Society Press",
pages = "429--432",
editor = "Alan Murray",
booktitle = "Computing in Cardiology Conference 2015, CinC 2015",
address = "United States",
note = "42nd Computing in Cardiology Conference, CinC 2015 ; Conference date: 06-09-2015 Through 09-09-2015",

}

RIS

TY - GEN

T1 - Adaptation of rabbit ventricular cell model to reproduce action potentials in isolated papillary muscle

AU - Jensen, Ask S.

AU - Pennisi, Cristian P.

AU - Sevcencu, Cristian

AU - Christensen, Jørn B.

AU - Kristiansen, Jette E.

AU - Struijk, Johannes J.

PY - 2015/2/16

Y1 - 2015/2/16

N2 - Aims: We sought to establish a computational model of the rabbit ventricular action potential (AP) suitable for investigation of drug effects on the AP of the isolated rabbit papillary muscle. Methods: Data consisted of transmembrane AP recordings from isolated right ventricular papillary muscles from 21 rabbits. An existing model of the rabbit ventricular AP was adapted to reproduce experimental AP amplitude and AP duration (APD90, APD60, APD30,) at multiple pacing rates by reduction of fast sodium current and overall depolarizing current. The resulting model was validated. Results: At 2.0 and 0.5 Hz pacing respectively, the experimentally recorded APD90 was 113.9±11.2 ms and 150.2±13.1 ms. The adapted model produced an APD90 of 130.5 ms and 142.5 ms. Validation of the adapted model showed that, while there was a substantial adaptation of the model APD to experimental data, model stability was maintained, and internal Ca dynamics and responses to stimuli were not substantially affected. Conclusion: A model of the rabbit ventricular AP was adapted in order to reproduce experimental AP recordings from the isolated right ventricular rabbit papillary muscle. This model is useful for analysis of drug effects on the rabbit papillary AP.

AB - Aims: We sought to establish a computational model of the rabbit ventricular action potential (AP) suitable for investigation of drug effects on the AP of the isolated rabbit papillary muscle. Methods: Data consisted of transmembrane AP recordings from isolated right ventricular papillary muscles from 21 rabbits. An existing model of the rabbit ventricular AP was adapted to reproduce experimental AP amplitude and AP duration (APD90, APD60, APD30,) at multiple pacing rates by reduction of fast sodium current and overall depolarizing current. The resulting model was validated. Results: At 2.0 and 0.5 Hz pacing respectively, the experimentally recorded APD90 was 113.9±11.2 ms and 150.2±13.1 ms. The adapted model produced an APD90 of 130.5 ms and 142.5 ms. Validation of the adapted model showed that, while there was a substantial adaptation of the model APD to experimental data, model stability was maintained, and internal Ca dynamics and responses to stimuli were not substantially affected. Conclusion: A model of the rabbit ventricular AP was adapted in order to reproduce experimental AP recordings from the isolated right ventricular rabbit papillary muscle. This model is useful for analysis of drug effects on the rabbit papillary AP.

U2 - 10.1109/CIC.2015.7408678

DO - 10.1109/CIC.2015.7408678

M3 - Article in proceedings

AN - SCOPUS:84964009404

T3 - Computing in Cardiology

SP - 429

EP - 432

BT - Computing in Cardiology Conference 2015, CinC 2015

A2 - Murray, Alan

PB - IEEE Computer Society Press

T2 - 42nd Computing in Cardiology Conference, CinC 2015

Y2 - 6 September 2015 through 9 September 2015

ER -

ID: 261046723