Amyloid-β and α-synuclein decrease the level of metal-catalyzed reactive oxygen species by radical scavenging and redox silencing
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- Pedersen_2016_amyloid-beta_and
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The formation of reactive oxygen species (ROS) is linked to the pathogenesis of Alzheimer's and Parkinson's diseases. Here we have investigated the effect of soluble and aggregated Aβ and α-synuclein, associated with Alzheimer's and Parkinson's disease respectively, on the Cu2+-catalyzed formation of ROS in vitro in the presence of a biological reductant. We find that the levels of ROS, and the rate by which ROS is generated, are significantly reduced when the Cu2+ is bound to Aβ or α-synuclein, particularly when they are in the oligomeric or fibrillar forms. This effect is attributed to a combination of radical scavenging and redox silencing mechanisms. Our findings suggest that the increase in ROS associated with the accumulation of aggregated Aβ or α-synuclein does not result from a particularly ROS-active form of these peptides, but rather from either a local increase of Cu2+ and other ROS-active metal ions in the aggregates or as a downstream consequence of the formation of the patho-logical amyloid structures.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Chemical Society |
Vol/bind | 138 |
Udgave nummer | 12 |
Sider (fra-til) | 3966-3969 |
Antal sider | 4 |
ISSN | 0002-7863 |
DOI | |
Status | Udgivet - 2016 |
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ID: 158550918