Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists

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Standard

Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists. / Minkwitz, Rolf; Meldal, Morten.

I: QSAR and Combinatorial Science, Bind 24, Nr. 3, 04.2005, s. 343-353.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Minkwitz, R & Meldal, M 2005, 'Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists', QSAR and Combinatorial Science, bind 24, nr. 3, s. 343-353. https://doi.org/10.1002/qsar.200420050

APA

Minkwitz, R., & Meldal, M. (2005). Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists. QSAR and Combinatorial Science, 24(3), 343-353. https://doi.org/10.1002/qsar.200420050

Vancouver

Minkwitz R, Meldal M. Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists. QSAR and Combinatorial Science. 2005 apr.;24(3):343-353. https://doi.org/10.1002/qsar.200420050

Author

Minkwitz, Rolf ; Meldal, Morten. / Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists. I: QSAR and Combinatorial Science. 2005 ; Bind 24, Nr. 3. s. 343-353.

Bibtex

@article{59baead37f094c279d02373690022924,
title = "Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists",
abstract = "A new photolabile backbone amide handle has been developed for the synthesis of a melanocortin subtype-4 receptor (MCR4) agonist library in the solid phase. This traceless linker allows for the solid-supported synthesis of internal amides and their release under very mild, orthogonal conditions from solid support. The chemistry to attach an amide onto the linker is discussed. Structural variations of the linker in order to facilitate the attachment are investigated. The cleavage rate on the solid phase was measured. Finally, a small arylpiperazine library towards the MCR4 receptor was synthesized and its members characterized via HPLC, MS and NMR.",
keywords = "Combinatorial chemistry, Handles, Libraries, Linkers, Solid-phase synthesis",
author = "Rolf Minkwitz and Morten Meldal",
year = "2005",
month = apr,
doi = "10.1002/qsar.200420050",
language = "English",
volume = "24",
pages = "343--353",
journal = "Molecular Informatics",
issn = "1868-1743",
publisher = "Wiley - V C H Verlag GmbH & Co. KGaA",
number = "3",

}

RIS

TY - JOUR

T1 - Application of a photolabile backbone amide linker for cleavage of internal amides in the synthesis towards melanocortin subtype-4 agonists

AU - Minkwitz, Rolf

AU - Meldal, Morten

PY - 2005/4

Y1 - 2005/4

N2 - A new photolabile backbone amide handle has been developed for the synthesis of a melanocortin subtype-4 receptor (MCR4) agonist library in the solid phase. This traceless linker allows for the solid-supported synthesis of internal amides and their release under very mild, orthogonal conditions from solid support. The chemistry to attach an amide onto the linker is discussed. Structural variations of the linker in order to facilitate the attachment are investigated. The cleavage rate on the solid phase was measured. Finally, a small arylpiperazine library towards the MCR4 receptor was synthesized and its members characterized via HPLC, MS and NMR.

AB - A new photolabile backbone amide handle has been developed for the synthesis of a melanocortin subtype-4 receptor (MCR4) agonist library in the solid phase. This traceless linker allows for the solid-supported synthesis of internal amides and their release under very mild, orthogonal conditions from solid support. The chemistry to attach an amide onto the linker is discussed. Structural variations of the linker in order to facilitate the attachment are investigated. The cleavage rate on the solid phase was measured. Finally, a small arylpiperazine library towards the MCR4 receptor was synthesized and its members characterized via HPLC, MS and NMR.

KW - Combinatorial chemistry

KW - Handles

KW - Libraries

KW - Linkers

KW - Solid-phase synthesis

UR - http://www.scopus.com/inward/record.url?scp=18344365619&partnerID=8YFLogxK

U2 - 10.1002/qsar.200420050

DO - 10.1002/qsar.200420050

M3 - Journal article

AN - SCOPUS:18344365619

VL - 24

SP - 343

EP - 353

JO - Molecular Informatics

JF - Molecular Informatics

SN - 1868-1743

IS - 3

ER -

ID: 326847434