Smog chamber techniques were used to study the Cl atom and OH radical initiated oxidation of 1,1-difluoroacetone (CF₂HC(O)CH₃) in 700 Torr of air or N₂ diluent at 297 K. Using relative rate methods k(Cl + CF₂HC(O)CH₃) = (5.0 ± 0.8) × 10⁻¹⁴ cm³ molecule^-1 s⁻¹ and k(OH + CF₂HC(O)CH₃) = (2.6 ± 0.7) × 10⁻¹⁴ cm³molecule^-1s⁻¹ were determined. The atmospheric lifetime of CF₂HC(O)CH₃ with respect to reaction with OH radicals is estimated at 1.2 years. Atmospheric oxidation yields COF₂, CO and CO₂. The data suggests that Cl atoms primarily attack the –CF₂H group, whereas OH radicals also attack the –CH₃ group.