FTIR smog chamber techniques were used to measure k(Cl + C2F5CH2OCH3) = (2.52 ± 0.37) × 10−11 and k(OH + C2F5CH2OCH3) = (5.78 ± 1.02) × 10−13 cm3 molecule−1 s−1 in 700 Torr of air diluent at 296 ± 1 K. The atmospheric lifetime of C2F5CH2OCH3 is estimated to be 20 days. Reaction of chlorine atoms with C2F5CH2OCH3 proceeds 18 ± 2% at the –CH2– group and 82 ± 2% at the –CH3 group. Reaction of OH radicals with C2F5CH2OCH3 proceeds 44 ± 5% at the –CH2– group and 56 ± 5% at the –CH3 group. The atmospheric fate of C2F5CH2OCH2O radicals is reaction with O2 to give C2F5CH2OCHO. The atmospheric fate of C2F5CH(O)OCH3 radicals is C–C bond-cleavage to give C2F5 radicals and CH3OCHO (methyl formate). The infrared spectrum was recorded and used to estimate a global warming potential of 6 (100 year time horizon) for C2F5CH2OCH3.