Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates. / Villadsen, Klaus; Martos Maldonado, Manuel Cristo; Jensen, Knud Jørgen; Thygesen, Mikkel Boas.
I: ChemBioChem, Bind 18, Nr. 7, 2017, s. 574-612.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates
AU - Villadsen, Klaus
AU - Martos Maldonado, Manuel Cristo
AU - Jensen, Knud Jørgen
AU - Thygesen, Mikkel Boas
PY - 2017
Y1 - 2017
N2 - Glycobiology is the comprehensive biological investigation of carbohydrates. The study of the role and function of complex carbohydrates often requires the attachment of carbohydrates to surfaces, their tagging with fluorophores, or their conversion into natural or non-natural glycoconjugates, such as glycopeptides or glycolipids. Glycobiology and its “omics”, glycomics, require easy and robust chemical methods for the construction of these glycoconjugates. This review gives an overview of the rapidly expanding field of chemical reactions that selectively convert unprotected carbohydrates into glycoconjugates through the anomeric position. The discussion is divided in terms of the anomeric bond type of the newly formed glycoconjugates, including O-, N-, S-, and C-glycosides.
AB - Glycobiology is the comprehensive biological investigation of carbohydrates. The study of the role and function of complex carbohydrates often requires the attachment of carbohydrates to surfaces, their tagging with fluorophores, or their conversion into natural or non-natural glycoconjugates, such as glycopeptides or glycolipids. Glycobiology and its “omics”, glycomics, require easy and robust chemical methods for the construction of these glycoconjugates. This review gives an overview of the rapidly expanding field of chemical reactions that selectively convert unprotected carbohydrates into glycoconjugates through the anomeric position. The discussion is divided in terms of the anomeric bond type of the newly formed glycoconjugates, including O-, N-, S-, and C-glycosides.
KW - carbohydrate–protein interactions
KW - glycan tagging
KW - glycobiology
KW - glycoconjugates
KW - glycoproteins
U2 - 10.1002/cbic.201600582
DO - 10.1002/cbic.201600582
M3 - Review
C2 - 28067438
AN - SCOPUS:85014036661
VL - 18
SP - 574
EP - 612
JO - ChemBioChem
JF - ChemBioChem
SN - 1439-4227
IS - 7
ER -
ID: 176610067