Cu-catalyzed azide - Alkyne cycloaddition

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Cu-catalyzed azide - Alkyne cycloaddition. / Meldal, Morten; Tomøe, Christian Wenzel.

I: Chemical Reviews, Bind 108, Nr. 8, 08.2008, s. 2952-3015.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Meldal, M & Tomøe, CW 2008, 'Cu-catalyzed azide - Alkyne cycloaddition', Chemical Reviews, bind 108, nr. 8, s. 2952-3015. https://doi.org/10.1021/cr0783479

APA

Meldal, M., & Tomøe, C. W. (2008). Cu-catalyzed azide - Alkyne cycloaddition. Chemical Reviews, 108(8), 2952-3015. https://doi.org/10.1021/cr0783479

Vancouver

Meldal M, Tomøe CW. Cu-catalyzed azide - Alkyne cycloaddition. Chemical Reviews. 2008 aug.;108(8):2952-3015. https://doi.org/10.1021/cr0783479

Author

Meldal, Morten ; Tomøe, Christian Wenzel. / Cu-catalyzed azide - Alkyne cycloaddition. I: Chemical Reviews. 2008 ; Bind 108, Nr. 8. s. 2952-3015.

Bibtex

@article{0979fcb7ad7241f2b9c94b36c54a7278,
title = "Cu-catalyzed azide - Alkyne cycloaddition",
abstract = "The copper catalysis in the Huisgen reaction broadly known as the azide/ alkyne reaction or CuAAC reaction has been discussed. This simple and robust reaction, which involves clusters of Cu and ligands, has led to exclusive formation of the 1,4-isomer. It is vital to maintain a good concentration of Cu throughout the reaction medium particularly in the case of less reactive reaction components or dilute reactions. The ligands' role in protecting the copper from oxidation or disproportionation is also important. The ligands also influence the structure and equilibria of copper clusters and may promote the formation of the most catalytically active copper complexes. The CuAAC reaction may be designed to accommodate all types of protecting groups and reactive intermediates.",
author = "Morten Meldal and Tom{\o}e, {Christian Wenzel}",
year = "2008",
month = aug,
doi = "10.1021/cr0783479",
language = "English",
volume = "108",
pages = "2952--3015",
journal = "Chemical Reviews",
issn = "0009-2665",
publisher = "American Chemical Society",
number = "8",

}

RIS

TY - JOUR

T1 - Cu-catalyzed azide - Alkyne cycloaddition

AU - Meldal, Morten

AU - Tomøe, Christian Wenzel

PY - 2008/8

Y1 - 2008/8

N2 - The copper catalysis in the Huisgen reaction broadly known as the azide/ alkyne reaction or CuAAC reaction has been discussed. This simple and robust reaction, which involves clusters of Cu and ligands, has led to exclusive formation of the 1,4-isomer. It is vital to maintain a good concentration of Cu throughout the reaction medium particularly in the case of less reactive reaction components or dilute reactions. The ligands' role in protecting the copper from oxidation or disproportionation is also important. The ligands also influence the structure and equilibria of copper clusters and may promote the formation of the most catalytically active copper complexes. The CuAAC reaction may be designed to accommodate all types of protecting groups and reactive intermediates.

AB - The copper catalysis in the Huisgen reaction broadly known as the azide/ alkyne reaction or CuAAC reaction has been discussed. This simple and robust reaction, which involves clusters of Cu and ligands, has led to exclusive formation of the 1,4-isomer. It is vital to maintain a good concentration of Cu throughout the reaction medium particularly in the case of less reactive reaction components or dilute reactions. The ligands' role in protecting the copper from oxidation or disproportionation is also important. The ligands also influence the structure and equilibria of copper clusters and may promote the formation of the most catalytically active copper complexes. The CuAAC reaction may be designed to accommodate all types of protecting groups and reactive intermediates.

UR - http://www.scopus.com/inward/record.url?scp=51049094897&partnerID=8YFLogxK

U2 - 10.1021/cr0783479

DO - 10.1021/cr0783479

M3 - Review

C2 - 18698735

AN - SCOPUS:51049094897

VL - 108

SP - 2952

EP - 3015

JO - Chemical Reviews

JF - Chemical Reviews

SN - 0009-2665

IS - 8

ER -

ID: 321827018