Since the discovery of the first hemicucurbit[n]uril macrocycles in 2004, a series of functional hemicucurbit[n]uril derivatives have been prepared and studies of their supramolecular chemistry have been conducted. The original hemicucurbit[n]urils (hemicucurbit[6]uril and hemicucurbit[12]uril) are only sparsely soluble, which hampered studies of their properties as potential hosts in supramolecular chemistry. Recently, a range of homologues have been synthesized (eg, the biotin[n]urils, the bambus[n]urils, and the cyclohexylhemicucurbit[n]urils) that are functionalizable and their supramolecular chemistry has been studied in a range of solvents. This has expanded the scope, and the interest in these structures is growing. In contrast to the more widely studied cucurbit[n]urils that are excellent hosts for cations, the hemicucurbit[n]urils act as hosts for anions. This article provides a comprehensive survey of the literature covering the syntheses of the homologs and derivatives, and their supramolecular chemistry