Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.
Originalsprog | Engelsk |
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Tidsskrift | Nature Chemical Biology |
Vol/bind | 11 |
Udgave nummer | 3 |
Sider (fra-til) | 192-194 |
Antal sider | 3 |
ISSN | 1552-4450 |
DOI | |
Status | Udgivet - 2015 |
ID: 131361806