'One bead two compound libraries' for detecting chemical and biochemical conversions

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

'One bead two compound libraries' for detecting chemical and biochemical conversions. / Meldal, Morten.

I: Current Opinion in Chemical Biology, Bind 8, Nr. 3, 06.2004, s. 238-244.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Meldal, M 2004, ''One bead two compound libraries' for detecting chemical and biochemical conversions', Current Opinion in Chemical Biology, bind 8, nr. 3, s. 238-244. https://doi.org/10.1016/j.cbpa.2004.04.007

APA

Meldal, M. (2004). 'One bead two compound libraries' for detecting chemical and biochemical conversions. Current Opinion in Chemical Biology, 8(3), 238-244. https://doi.org/10.1016/j.cbpa.2004.04.007

Vancouver

Meldal M. 'One bead two compound libraries' for detecting chemical and biochemical conversions. Current Opinion in Chemical Biology. 2004 jun.;8(3):238-244. https://doi.org/10.1016/j.cbpa.2004.04.007

Author

Meldal, Morten. / 'One bead two compound libraries' for detecting chemical and biochemical conversions. I: Current Opinion in Chemical Biology. 2004 ; Bind 8, Nr. 3. s. 238-244.

Bibtex

@article{6118104a8b154898a132922d1eb0b0dc,
title = "'One bead two compound libraries' for detecting chemical and biochemical conversions",
abstract = "When combinatorial chemistry was introduced 13 years ago, the expectations were high for the delivery of results, particularly in the pharmaceutical industry. However, combinatorial chemistry was implemented independently of the application for which the products were going to be used. Resins developed only for efficient solid-phase synthesis were used and products were employed in existing assays developed for traditional solution studies. There was almost no assay or technology development and the use of real combinatorial methods soon had to give way to high-throughput synthesis and traditional screening. However, during recent years more sophisticated resins and assay techniques have been developed that may result in a second and more successful inplementation of real integrated combinatorial chemistry. The first in this line of new developments is the 'one bead two compound' assay, in which the resin bead in addition to a combinatorial library member contains a reporter compound that can act as a beacon to monitor the activity of the library member. This powerful concept can be generally applied in all fields of combinatorial chemistry including drug, catalysts and material development.",
keywords = "dimethoxy-trityl, DMT",
author = "Morten Meldal",
year = "2004",
month = jun,
doi = "10.1016/j.cbpa.2004.04.007",
language = "English",
volume = "8",
pages = "238--244",
journal = "Current Opinion in Chemical Biology",
issn = "1367-5931",
publisher = "Elsevier Ltd. * Current Opinion Journals",
number = "3",

}

RIS

TY - JOUR

T1 - 'One bead two compound libraries' for detecting chemical and biochemical conversions

AU - Meldal, Morten

PY - 2004/6

Y1 - 2004/6

N2 - When combinatorial chemistry was introduced 13 years ago, the expectations were high for the delivery of results, particularly in the pharmaceutical industry. However, combinatorial chemistry was implemented independently of the application for which the products were going to be used. Resins developed only for efficient solid-phase synthesis were used and products were employed in existing assays developed for traditional solution studies. There was almost no assay or technology development and the use of real combinatorial methods soon had to give way to high-throughput synthesis and traditional screening. However, during recent years more sophisticated resins and assay techniques have been developed that may result in a second and more successful inplementation of real integrated combinatorial chemistry. The first in this line of new developments is the 'one bead two compound' assay, in which the resin bead in addition to a combinatorial library member contains a reporter compound that can act as a beacon to monitor the activity of the library member. This powerful concept can be generally applied in all fields of combinatorial chemistry including drug, catalysts and material development.

AB - When combinatorial chemistry was introduced 13 years ago, the expectations were high for the delivery of results, particularly in the pharmaceutical industry. However, combinatorial chemistry was implemented independently of the application for which the products were going to be used. Resins developed only for efficient solid-phase synthesis were used and products were employed in existing assays developed for traditional solution studies. There was almost no assay or technology development and the use of real combinatorial methods soon had to give way to high-throughput synthesis and traditional screening. However, during recent years more sophisticated resins and assay techniques have been developed that may result in a second and more successful inplementation of real integrated combinatorial chemistry. The first in this line of new developments is the 'one bead two compound' assay, in which the resin bead in addition to a combinatorial library member contains a reporter compound that can act as a beacon to monitor the activity of the library member. This powerful concept can be generally applied in all fields of combinatorial chemistry including drug, catalysts and material development.

KW - dimethoxy-trityl

KW - DMT

UR - http://www.scopus.com/inward/record.url?scp=2942555084&partnerID=8YFLogxK

U2 - 10.1016/j.cbpa.2004.04.007

DO - 10.1016/j.cbpa.2004.04.007

M3 - Review

C2 - 15183321

AN - SCOPUS:2942555084

VL - 8

SP - 238

EP - 244

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

SN - 1367-5931

IS - 3

ER -

ID: 327947990