TY - JOUR

T1 - Polymer "clicking" by CuAAC reactions

AU - Meldal, Morten

PY - 2008/7/1

Y1 - 2008/7/1

N2 - The CuAAC "click" reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust. The formed triazole on the other hand is of intermediate polarity and chemically and biochemically "invisible", and the CuAAC provides the ideal "click" reaction for stitching together polymer architectures of unprecedended complexity as was it molecular LEGO. The CuAAC "clicking" in polymer chemistry is increasing exponentially and lead to highly defined polymer materials with novel properties.

AB - The CuAAC "click" reaction has developed as one of the most useful and widely employed reactions in ligation within polymer chemistry. This is due to the unique properties of the Cu(I) catalysis which renders the reaction quantitative even at low concentrations, orthogonal with other chemistries and extremely robust. The formed triazole on the other hand is of intermediate polarity and chemically and biochemically "invisible", and the CuAAC provides the ideal "click" reaction for stitching together polymer architectures of unprecedended complexity as was it molecular LEGO. The CuAAC "clicking" in polymer chemistry is increasing exponentially and lead to highly defined polymer materials with novel properties.

KW - Catalytic polymer formation

KW - CuAAC "click" polymerization

KW - High performance polymers

KW - Star polymers

KW - Triazole grafted copolymers

UR - http://www.scopus.com/inward/record.url?scp=55049090701&partnerID=8YFLogxK

U2 - 10.1002/marc.200800159

DO - 10.1002/marc.200800159

M3 - Review

AN - SCOPUS:55049090701

VL - 29

SP - 1016

EP - 1051

JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

SN - 1022-1336

IS - 12-13

ER -