Solid-phase synthesis of complex and pharmacologically interesting heterocycles

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Solid-phase synthesis of complex and pharmacologically interesting heterocycles. / Nielsen, Thomas E.; Meldal, Morten.

I: Current Opinion in Drug Discovery and Development, Bind 12, Nr. 6, 11.2009, s. 798-810.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Nielsen, TE & Meldal, M 2009, 'Solid-phase synthesis of complex and pharmacologically interesting heterocycles', Current Opinion in Drug Discovery and Development, bind 12, nr. 6, s. 798-810.

APA

Nielsen, T. E., & Meldal, M. (2009). Solid-phase synthesis of complex and pharmacologically interesting heterocycles. Current Opinion in Drug Discovery and Development, 12(6), 798-810.

Vancouver

Nielsen TE, Meldal M. Solid-phase synthesis of complex and pharmacologically interesting heterocycles. Current Opinion in Drug Discovery and Development. 2009 nov.;12(6):798-810.

Author

Nielsen, Thomas E. ; Meldal, Morten. / Solid-phase synthesis of complex and pharmacologically interesting heterocycles. I: Current Opinion in Drug Discovery and Development. 2009 ; Bind 12, Nr. 6. s. 798-810.

Bibtex

@article{80e41d72976945fd98bf5893840f8ea1,
title = "Solid-phase synthesis of complex and pharmacologically interesting heterocycles",
abstract = "Efficient routes for the creation of heterocycles continue to be one of the primary goals for solid-phase synthesis. Recent advances in this field rely most notably on transition-metal-catalysis and N-acyliminium chemistry to mediate a range of cyclization processes for the generation of compounds with significant structural complexity and diversity. This review describes some of the most systematic solid-phase approaches that are potentially suited for pharmaceutical applications, that is, the methods described are useful for the synthesis of compound collections, and exhibit tunable stereochemistry, scaffold structure, and appendage modification.",
keywords = "Combinatorial chemistry, Heterocycle, N-acyliminium chemistry, Pictet-Spengler reaction, Solid-phase synthesis",
author = "Nielsen, {Thomas E.} and Morten Meldal",
year = "2009",
month = nov,
language = "English",
volume = "12",
pages = "798--810",
journal = "Current Opinion in Drug Discovery and Development",
issn = "1367-6733",
publisher = "Current Drugs Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Solid-phase synthesis of complex and pharmacologically interesting heterocycles

AU - Nielsen, Thomas E.

AU - Meldal, Morten

PY - 2009/11

Y1 - 2009/11

N2 - Efficient routes for the creation of heterocycles continue to be one of the primary goals for solid-phase synthesis. Recent advances in this field rely most notably on transition-metal-catalysis and N-acyliminium chemistry to mediate a range of cyclization processes for the generation of compounds with significant structural complexity and diversity. This review describes some of the most systematic solid-phase approaches that are potentially suited for pharmaceutical applications, that is, the methods described are useful for the synthesis of compound collections, and exhibit tunable stereochemistry, scaffold structure, and appendage modification.

AB - Efficient routes for the creation of heterocycles continue to be one of the primary goals for solid-phase synthesis. Recent advances in this field rely most notably on transition-metal-catalysis and N-acyliminium chemistry to mediate a range of cyclization processes for the generation of compounds with significant structural complexity and diversity. This review describes some of the most systematic solid-phase approaches that are potentially suited for pharmaceutical applications, that is, the methods described are useful for the synthesis of compound collections, and exhibit tunable stereochemistry, scaffold structure, and appendage modification.

KW - Combinatorial chemistry

KW - Heterocycle

KW - N-acyliminium chemistry

KW - Pictet-Spengler reaction

KW - Solid-phase synthesis

UR - http://www.scopus.com/inward/record.url?scp=70350749437&partnerID=8YFLogxK

M3 - Review

C2 - 19894191

AN - SCOPUS:70350749437

VL - 12

SP - 798

EP - 810

JO - Current Opinion in Drug Discovery and Development

JF - Current Opinion in Drug Discovery and Development

SN - 1367-6733

IS - 6

ER -

ID: 321825105