The Pictet-Spengler reaction in solid-phase combinatorial chemistry
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The Pictet-Spengler reaction in solid-phase combinatorial chemistry. / Nielsen, Thomas E; Diness, Frederik; Meldal, Morten.
I: Current Opinion in Drug Discovery & Development, Bind 6, Nr. 6, 11.2003, s. 801-14.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The Pictet-Spengler reaction in solid-phase combinatorial chemistry
AU - Nielsen, Thomas E
AU - Diness, Frederik
AU - Meldal, Morten
PY - 2003/11
Y1 - 2003/11
N2 - The Pictet-Spengler reaction is an important reaction for the generation of tetrahydro-beta-carbolines and tetrahydroisoquinoline ring systems, which exhibit a range of biological and pharmacological properties. This review covers the solid-phase Pictet-Spengler reaction, as employed in solid-phase routes toward a range of complex heterocyclic ring systems, with focus on experimental conditions, efficiency and diastereoselectivity. This is illustrated by the application of this reaction to the synthesis of combinatorial libraries, natural product analogs and drug-like scaffolds.
AB - The Pictet-Spengler reaction is an important reaction for the generation of tetrahydro-beta-carbolines and tetrahydroisoquinoline ring systems, which exhibit a range of biological and pharmacological properties. This review covers the solid-phase Pictet-Spengler reaction, as employed in solid-phase routes toward a range of complex heterocyclic ring systems, with focus on experimental conditions, efficiency and diastereoselectivity. This is illustrated by the application of this reaction to the synthesis of combinatorial libraries, natural product analogs and drug-like scaffolds.
KW - Carbolines
KW - Chemistry, Pharmaceutical
KW - Combinatorial Chemistry Techniques
KW - Denmark
KW - Heterocyclic Compounds
KW - Molecular Structure
KW - Tetrahydroisoquinolines
M3 - Journal article
C2 - 14758752
VL - 6
SP - 801
EP - 814
JO - Current Opinion in Drug Discovery and Development
JF - Current Opinion in Drug Discovery and Development
SN - 1367-6733
IS - 6
ER -
ID: 158554756