Metal halide perovskites showing responses to external stimuli have emerged as a new class of stimulus-responsive smart materials. Specifically, their photoluminescence (PL) intensity, color and lifetime can change with different external stimuli. However, most of the existing metal halide perovskites only show PL response to a single stimulus. For encryption security applications, it is desired to have selective PL response to multiple stimuli. Herein, we developed a new type of cesium (Cs) manganese (Mn) bromide (Br) perovskite (Cs₂MnBr₄(H₂O)₂) single crystal with PL response to temperature, humidity and solvent by taking advantage of its structural phase transition, which causes its PL intensity (from non-luminescent to near unity luminescence) and color change (from green to red). Stimuli-responsive PL can be achieved by engineering the phase structure of Cs-Mn-Br perovskites from Cs₂MnBr₄(H₂O)₂ to Cs₂MnBr₄, Cs₃MnBr₅, CsMnBr₃(H₂O)₂ and CsMnBr₃ via temperature and different solvents. Such multiple stimuli responsive material is promising for multidimensional information encryption.