Two different experimental techniques were used to study the kinetics of the reaction of OH radicals with trifluoroacetic acid, CF₃COOH. Using a pulse radiolysis absolute rate technique, rate constants at 315 and 348 K were determined to be (1.6±0.4)×10^-13 and (1.5±0.2)×10^-13 cm³ molecule^-1 s^-1, respectively. Using a long path-length FTIR relative rate technique a rate constant of (1.7±0.5)×10^-13 cm³ molecule^-1 s^-1 was obtained at 296 K. In the atmosphere, reaction with OH radicals in the gas phase is estimated to account for 10%-20% of the loss of CF₃COOH. The major fate of CF₃COOH is rainout.