Rate constants for the reactions of OH radicals with (CH₃)₄Pb and (C₂H₅)₄Pb have been determined at 298 ± 2 K and a total pressure of approximately 1 atm. Rate data were obtained by using both the absolute rate technique of pulse radiolysis combined with kinetic spectroscopy and a conventional photolytic relative rate method. Rate constants were also obtained for the analogous reactions with (CH₃)₄C and (C₂H₅)₄C for comparison purposes. The results are discussed in terms of structure-reactivity relationships. Values of the rate constants (10^-12 cm³ molecule^-1 s^-1) are [formula omited].