Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides. / Nielsen, Thomas E.; Le Quement, Sebastian T.; Meldal, Morten.

I: Organic Letters, Bind 9, Nr. 13, 21.06.2007, s. 2469-2472.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, TE, Le Quement, ST & Meldal, M 2007, 'Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides', Organic Letters, bind 9, nr. 13, s. 2469-2472. https://doi.org/10.1021/ol070693p

APA

Nielsen, T. E., Le Quement, S. T., & Meldal, M. (2007). Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides. Organic Letters, 9(13), 2469-2472. https://doi.org/10.1021/ol070693p

Vancouver

Nielsen TE, Le Quement ST, Meldal M. Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides. Organic Letters. 2007 jun. 21;9(13):2469-2472. https://doi.org/10.1021/ol070693p

Author

Nielsen, Thomas E. ; Le Quement, Sebastian T. ; Meldal, Morten. / Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides. I: Organic Letters. 2007 ; Bind 9, Nr. 13. s. 2469-2472.

Bibtex

@article{3fe12c36cfda4e44acbb6375f448a83b,
title = "Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides",
abstract = "A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.",
author = "Nielsen, {Thomas E.} and {Le Quement}, {Sebastian T.} and Morten Meldal",
year = "2007",
month = jun,
day = "21",
doi = "10.1021/ol070693p",
language = "English",
volume = "9",
pages = "2469--2472",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "13",

}

RIS

TY - JOUR

T1 - Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides

AU - Nielsen, Thomas E.

AU - Le Quement, Sebastian T.

AU - Meldal, Morten

PY - 2007/6/21

Y1 - 2007/6/21

N2 - A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.

AB - A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.

UR - http://www.scopus.com/inward/record.url?scp=34547211174&partnerID=8YFLogxK

U2 - 10.1021/ol070693p

DO - 10.1021/ol070693p

M3 - Journal article

C2 - 17518476

AN - SCOPUS:34547211174

VL - 9

SP - 2469

EP - 2472

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 13

ER -

ID: 321882730