Solid-phase synthesis of carboxylic and oxamic acids via OsO 4/NaIO4/HMTA-mediated oxidative cleavage of acetylenic peptides
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
A general method for the solid-phase synthesis of carboxy-functionalized peptides by oxidative cleavage of alkynes is presented. Clean and quantitative conversion is enabled by the addition of bases, such as DABCO and HMTA, to the classical OsO4/NaIO4 mixture. The utility of the reaction is further illustrated by the synthesis of oxamic acids.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Organic Letters |
| Vol/bind | 9 |
| Udgave nummer | 13 |
| Sider (fra-til) | 2469-2472 |
| Antal sider | 4 |
| ISSN | 1523-7060 |
| DOI | |
| Status | Udgivet - 21 jun. 2007 |
| Eksternt udgivet | Ja |
ID: 321882730